Global Statistics

All countries
240,188,856
Confirmed
Updated on 14/10/2021 6:43 pm
All countries
215,765,598
Recovered
Updated on 14/10/2021 6:43 pm
All countries
4,893,161
Deaths
Updated on 14/10/2021 6:43 pm

Global Statistics

All countries
240,188,856
Confirmed
Updated on 14/10/2021 6:43 pm
All countries
215,765,598
Recovered
Updated on 14/10/2021 6:43 pm
All countries
4,893,161
Deaths
Updated on 14/10/2021 6:43 pm

Alzheimer’s disease: hyperbaric oxygen proposed as a treatment in a new study

PRI ESPL INT .SHEFFIELD FES10 ALZHEIMER-TREATMENT Alzheimer’s Disease: Hyperbaric Oxygen Proposed as Treatment in New Study By Osman Shabir, Postdoctoral Research Associate, University of Sheffield Sheffield, UK, September 16 (The Conversation) Alzheimer’s Disease, The most common form of dementia, it has long been associated with the accumulation of plaques (groups of proteins) in the brain. Scientists from Israel have shown that a type of oxygen therapy can stop the formation of new plaques and even eliminate existing plaques in mice with Alzheimer’s. The scientists used a mouse model of Alzheimer’s disease called 5xFAD. The genetically modified mice were treated with hyperbaric oxygen therapy to see if they could stop or slow the progression of the disease. Hyperbaric oxygen therapy involves breathing pure oxygen in a pressurized chamber. In the chamber, the air pressure increases two to three times higher than normal air pressure. It is commonly used to treat decompression sickness (a condition divers can suffer from), carbon monoxide poisoning, and some forms of stroke or brain injury. It works by forcing a greater oxygenation of tissues with low oxygen levels (hypoxia). And it could improve blood flow to the brain to nourish brain cells that generally lack blood and therefore oxygen in Alzheimer’s disease. The scientists, from Tel Aviv University, treated 15 six-month-old mice (about 30 human years) with hyperbaric oxygen therapy for one hour a day, five days a week for four weeks. The therapy not only reduced the number and size of plaques in the mice’s brains, it also slowed the formation of new plaques, compared to a control group of mice that did not receive hyperbaric oxygen therapy. Blood flow to the brain is reduced in people with Alzheimer’s. This study showed increased blood flow to the brain in mice that received oxygen therapy, which helps remove plaques from the brain and reduces inflammation, a hallmark of Alzheimer’s. By improving blood flow to the brain, reducing plaque levels, and reducing hypoxia, mice undergoing daily oxygen therapy began to show improvements in their cognitive abilities, such as their spatial recognition memory, as well as contextual memory, the ability to recall. emotional, social, spatial. or temporary circumstances related to an event. Not Just Mice The researchers used these findings to evaluate the effectiveness of oxygen therapy in six cognitively impaired people older than 65. They found that 60 sessions of oxygen therapy, for 90 days, increased blood flow in certain areas of the brain and significantly improved the cognitive abilities of patients, improved memory, attention and the speed of information processing. An earlier study found that oxygen therapy reduced plaques in the brain in another mouse model of Alzheimer’s disease. And, before that, my colleagues and I published a study in Scientific Reports that showed that pure oxygen at normal atmospheric pressure can increase the volume of blood in the brains of six-month-old mice with Alzheimer’s disease, and this can increase. the removal of plaques from the brain. Together, these findings suggest that oxygen therapy can reduce cognitive decline associated with aging and dementia in both mice and people. I don’t think this can cure Alzheimer’s in humans, Professor Uri Ashery, the lead author of the research, told The Times of Israel, but it could significantly slow its progression and severity. However, it is important to note that the Israeli study was too small to draw firm conclusions. Also, 60 sessions of pressurized oxygen therapy lasting one hour each are simply not feasible for most people. Hyperbaric oxygen therapy cannot yet be offered at home or in a nursing home, where the majority of people with Alzheimer’s are found. And daily visits to a hospital or clinic are not practical for most people with the disease. The cameras cost up to 100,000, with an additional 1,500 in maintenance annually. And treatments cost between 40 and 250 per session. Given that there are close to a million people with dementia in the UK alone, it is clear that offering every patient hyperbaric oxygen therapy for 60 days is currently neither feasible nor financially viable. And the results, while promising in mice, have yet to be confirmed in people with Alzheimer’s in large clinical trials. (The conversation) NSA NSA 09161024 NNNN

(Business Standard staff may have only modified the title and image of this report; the rest of the content is automatically generated from a syndicated feed.)

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