Sunday, December 4, 2022
Home TECH AI can design new proteins and unlock new materials to heal

AI can design new proteins and unlock new materials to heal

The new tool, ProteinMPNN, described by a group of researchers from the University of Washington in two articles published in Science today (available here other here), offers a powerful complement to that technology.

The papers are the latest example of how deep learning is revolutionizing protein design by giving scientists new research tools. Traditionally, researchers design proteins by modifying those that occur in nature, but ProteinMPNN will open up a whole new universe of possible proteins for researchers to design from scratch.

“In nature, proteins basically solve all of life’s problems, from harvesting energy from sunlight to making molecules. Everything in biology happens from proteins,” says David Baker, one of the scientists behind the article and director of the Institute for Protein Design at the University of Washington.

“They evolved throughout evolution to solve problems that organisms faced during evolution. But today we are facing new problems, like covid. If we could design proteins that were as good at solving new problems as the ones that evolved during evolution are at solving old problems, that would be very, very powerful.”

Proteins consist of hundreds of thousands of amino acids that are linked together in long chains, which are then folded into three-dimensional shapes. AlphaFold helps researchers predict the resulting structure, providing insights into how they will behave.

ProteinMPNN will help researchers with the reverse problem. If you already have an exact protein structure in mind, it will help you find the sequence of amino acids that folds into that shape. The system uses a neural network trained on a large number of exemplary amino acid sequences, which fold into three-dimensional structures.

But the researchers also need to solve another problem. To design proteins that tackle real-world problems, such as a new plastic-digesting enzyme, they first have to figure out what protein structure would do the job.

To do this, researchers in the Baker lab use two machine learning methods, detailed in a Article in Science last July, which the team calls “restricted hallucination” and “in painting.”



Elon Musk says Twitter will give ‘amnesty’ to suspended accounts starting next week

If Twitter looks like a garbage fire right now, just wait. CEO Elon Musk announced a blanket pardon for nearly all suspended accounts...

Officials Seek Fixes For Exploding E-Bike Batteries – NPR

Electric bicycles are becoming fashionable. But damaged or improperly charged batteries can explode and start deadly fires,...


Please enter your comment!
Please enter your name here

- Advertisment -

Most Popular

Georgia Supreme Court reinstates state ban on abortions after about six weeks of pregnancy

Georgia Supreme Court reinstates state ban on abortions after about six weeks of pregnancy

Adderall and amoxicillin shortages raise questions about transparency at Big Pharma

Critical shortages of the ADHD drug Adderall and the antibiotic amoxicillin have left families reeling as the medications their loved ones need become harder...

Humberside Police judged ‘outstanding’ five years after being classified as failing | politics

A police force has gone from being classified as a failure five years ago to receiving the highest ratings in the modern era from...

Readers discuss Trump devotees, Republican love of guns and healthy eating – New York Daily News

Medford, LI: On successive news days this Thanksgiving week, I read that US Attorney General Merrick Garland has appointed a special prosecutor to investigate...